Endocrine Abstracts

Background: Foetus is protected from high quantities of steroids by placental enzyme 11BHSD2. It converts steroids to inactive form (dexamethasone and betamethasone are exceptions). Exposure to high steroids for long time could saturate the enzyme. Maternal steroid use carries a theoretical risk for neonatal adrenal insufficiency (AI). The evidence remains controversial and most NICUs don’t check for AI in those infants. Two units in south Yorkshire recom...

17 β-Hydroxysteroid Dehydrogenase Type 3 (17β-HSD3) deficiency is an autosomal recessive condition causing 46, XY disorder of sexual development (DSD). The enzyme is responsible for converting of Δ4-Androstenedione (A) to testosterone (T) in testicles. Affected individuals may present with abnormalities of the external genitalia at birth or during childhood and teenage years with virilisation or primary amenorrhea. The aim of this case series is to review the cl...